Works from the first week and each week thereafter. RoC Retinol Correxion Deep Wrinkle Night Cream visibly reduces the look of expression lines and deep wrinkles while you sleep. This cream containing pure RoC Retinol and an essential mineral complex leaves skin smooth and younger-looking. Tested by dermatologists and clinically proven to visibly reduce both fine lines and deep wrinkles in 12 weeks RoC Retinol Correxion Deep Wrinkle Night Cream is oil-free and noncomedogenic.